Clinical Trial Patient Recruitment Case Study: Alzheimer's Disease

Clinical trial patient recruitment can be difficult for Alzheimer's disease trials, particularly for prodromal Alzheimer's. Increasingly, sponsors are turning to Alzheimer's patient registries for help. Here, we'll share an Alzheimer's registry recruitment case study that demonstrates the need for community engagement and precision matching for these types of projects.

The challenge

Our client was a pharmaceutical company looking to develop a registry of 10,000 patients who showed very early symptoms of Alzheimer's disease, but had not yet been diagnosed. The client hoped to use this registry to help with design and recruitment for future Alzheimer's trials.

In addition to the challenge of quickly developing a registry that big, the sponsor anticipated difficulty locating not-yet-diagnosed but symptomatic patients. Many such patients are unwilling or unable to admit that they are experiencing memory problems, so it was difficult to find those not too far advanced in their journey with Alzheimer's. In addition, the trial required quite a bit of follow-up from patients, in the form of surveys.

They came to Antidote to connect with patients at scale.

Our solution

When our client shared their goal of completing their registry in just two months, and tapped Antidote to fill 80% of it, we embarked on a massive outreach mission.

First, we developed a custom landing page and prescreener that patients could take in just a few minutes to determine their eligibility for the registry. We launched the site and began to drive traffic by targeting people experiencing memory or cognitive issues who were worried about the possibility of Alzheimer's disease.

Traffic flowed from our partners' websites. Antidote collaborates with hundreds of patient advocacy organizations and health communities who embed Antidote Match, our patient-friendly clinical trial search engine, on their websites. Fortunately, we partner with several vibrant Alzheimer's patient advocacy groups that informed their communities about the new registry and encouraged people experiencing memory loss (or their loved ones) to sign up.

Antidote also employed digital outreach methods on social media and search platforms. We used proprietary data to build custom data models of eligible registrations to reach those who may experience early Alzheimer's Disease symptoms.

As thousands of patients completed the prescreener, we added another layer of eligibility check with phone screening. Our dedicated team of Patient Liaison Managers conducted sample checks of patient interest and motivation by phone. This allowed Antidote to identify and quickly scale efforts with partners and platforms that delivered the highest quality referrals.


Antidote delivered on time and on budget. With our blend of meaningful partner outreach and digital marketing, we were able to drive more than 166,000 visitors to the website, of whom 27,110 registered.

In total, our efforts resulted in 8,000 referred patients in less than two months.

Perhaps most importantly, our client was extremely impressed with the quality of our referrals, who were highly engaged patients interested in being on the registry. Antidote's referrals were reportedly 7x more likely to complete the required follow-up than referrals from other sources.