Contribute to Heart Failure Research
The MARITIME-HF clinical study offers an opportunity to play an important role in exploring a potential treatment for people who are living with heart failure (HF) and obesity. We know that HF and obesity are complex diseases that affect people in different ways. If eligible, you may play a role in advancing medical research that may make a difference for others facing similar challenges.
Study Participation
Your involvement may play a role in helping us understand heart failure (HF) and obesity and a potential option for reducing HF-related symptoms.
How long will the study last?
Participants will be enrolled in this study for a total of 1-5 years.
- Screening will take up to 4 weeks to complete.
- The study treatment period for this is being completed in 2 parts. If eligible, participants will enter part 1 and receive the investigational medicine or placebo for up to 3.5 years. If you join and complete Part 1, you will have the option to join Part 2 and receive the investigational medicine for 2 years. If you decide not to enter Part 2, you will enter the safety follow-up period.
- There is a safety follow-up period after the treatment period where participants will be monitored by the study doctor and team for about 4 months after the last dose of investigational medicine.
Investigational Medicine Overview
Scientists have developed an investigational medicine called maridebart cafraglutide, also known as MariTide. The MARITIME-HF clinical study will investigate MariTide’s safety and effectiveness in reducing HF-related symptoms and risk of hospitalization for people who are living with heart failure and obesity.
Will I receive MariTide?
Participants will either receive the investigational medicine, MariTide, or a placebo. The placebo looks like the investigational medicine but does not contain the drug and has no medical effect. Neither you nor the study doctor would know which treatment you are assigned to.
Lifestyle Counseling
As part of the study, you will receive guidance on nutrition and physical activity from qualified staff, starting after you enroll into the study until Part 1 of the study is complete. The nutritional counseling will help you maintain a targeted calorie reduction. We’ll also provide support and suggestions to gradually increase your physical activity over time.
You, or someone you care for, may be able to take part in the MARITIME-HF clinical study if you/they:
- are 18 years of age or older,
- are living with heart failure and are receiving treatment for it
- are living with obesity, which means having a body mass index (BMI) of 30 kg/m² or more
Other criteria apply. In addition, you will not be eligible if you have a previous or planned obesity-related surgery, have a history of cancer or pancreatitis, or may be pregnant or plan to become pregnant while enrolled in the study.
