What is IWRS in Clinical Research?

Even if you’ve been working in clinical research for a while, it can still be a challenge to stay on top of the many acronyms that come up in your work day. Three that often cause confusion are IWRS, IVRS, and IRT.

Basically, all three refer to the technology clinical research sites use to control patient randomization and drug supply in clinical trials. IRT (Interactive Response Technology) is the umbrella term that refers to both types of systems.

IVRS (Interactive Voice Response Systems): Used before internet connections were commonplace at all sites, this technology allows site administrators to interact with a database by pressing keypad buttons on a phone. The administrator follows voice prompts in order to enter in information.

IWRS (Interactive Web Response System): This system works the same way as IVRS, only with computer prompts rather than phone prompts. They can integrate with other systems automatically, so you can easily connect with patient data or lab eligibility results, for example. Most sites have migrated to IWR systems from IVR systems in recent years.

Both systems can be used remotely from any location, which is why they’re so helpful for trials with multiple sites. They both use central databases to hold all information, so it’s easy to keep track of.

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What are IWRS and IVRS used for in clinical research?

Patient management: With these systems, you can both register new patients and randomize patients into a trial. Some vendors allow you to integrate your unique randomization algorithm into the tool.

Supply chain management: With an IRT, you can control the inventory of your study drug. It also makes it easier to manage complex dispensing protocols, such as titration studies, and calculate dose. Some newer tools and updates also include an algorithm that can predict when you will run low on a study drug to help with supply chain management.

Documentation and reporting: Automated system reports allow study managers to easily access real-time information about your trial.

Integration with other systems: When choosing a vendor, ask whether their IWRS will integrate with your site’s existing systems, such as your clinical trial management system, Electronic Data Capture (EDC) system for capturing clinical trial data, etc.

Today's IWRS can easily communicate with other clinical trial technology systems.

IRT (IVRS/IWRS) Vendors:

Some IRT vendors focus exclusively on IVR/IWR systems, while others also offer additional technologies that clinical sites use. The below companies are the most prominent in the dedicated IRT space.

Clinitec

Features:

  • Cloud-based
  • Subject enrollment tracking
  • Randomization
  • Supply chain management
  • Integration with third party EDC, CTMS, eCOA and other systems

ITclinical

  • Volunteer enrollment tracking
  • Randomization
  • Supply chain management
  • Include your study’s custom randomization algorithm

Medpace

Features:

  • Volunteer enrollment tracking
  • Randomization
  • Supply chain management
  • Integration with central lab eligibility systems

PPD

Features:

  • Volunteer enrollment tracking
  • Randomization
  • Supply chain management
  • Reporting on current status, trends and projections

Veracity Logic

Features:

  • Volunteer enrollment tracking
  • Randomization
  • Supply chain management
  • Shipping and inventory control
  • Integration with EDC, CTMS and ePRO systems
  • Predictive resupply for trial drugs

YPrime

Features:

  • Volunteer enrollment tracking
  • Randomization
  • Supply chain management
  • Single platform with the company’s eCOA

Managing patient randomization and the study drug supply chain are just part of the clinical trial recruitment process. If you’re struggling to find patients who are the right fit for you trial, learn how Antidote can help. Learn about how Antidote can help you find the right patients to enroll in your trials.